Publications

2020

Santarella,F., Sridharan,R., Marinkovic, M., Farias, Correa, D., Amaral,RJ., Cavanagh,B., Smith,A., Garlick, J., O’Brien,F., Kearney,C. Scaffolds functionalized with matrix from induced pluripotent stem cell fibroblasts for diabetic wound healing. 2020;9(16):e2000307.

LeClair AM, Kotzias V, Garlick J, Cole AM, Kwon SC, Lightfoot A, et al. Facilitating stakeholder engagement in early stage translational research. PLoS ONE 15(7): e0235400. https://doi.org/10.1371/journal.pone.0235400

Quantina, P.,Ghazia, p., Pereira, U., Smith, A., Degardin, L.,Vignerona, P.,Ficheuxa, H.,Garlick, J.,Rapettib, L.,Egles C. Utilization of a mouse/human chimeric model for long term metabolic testing of human skin. J Pharmacol Toxicol Methods, 102:106663. doi: 10.1016/j.vascn.2019.106663.

2019

Smith,A., Huang,M., Watkins,T., Burguin,F., Baskin, J.,,Garlick, J.  De novo production of human extracellular matrix supports increased throughput and cellular complexity in 3D skin equivalent model. J Tissue Eng Regen Med. 2020;14(8):1019-1027

Garlick, J.A.., Soisson, A., Bergom, I., Design and Impact of an Undergraduate Civic Science Course.  Journal of College Science Teaching, (in press,  2019).

Huang M, Cai G, Baugh L, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski L, Trojanowska M, Georgakoudi I, Black L, Pioli P, Whitfield M, Garlick J (2019) Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through LOXL4: New Evidence from 3D Skin-like Tissues. Arthritis Rheumatol. 2019 Nov 9. doi: 10.1002/art.41163.

2018

Huang M, Liu Z, Baugh L, DeFuria J, Maione A, Smith A, Kashpur O, Black III LD, Georgakoudi I, Whitfield ML, Garlick J.  Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues. Lab Invest. 2019;99(4):514-527. 

Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC.  An antiviral branch of the IL-1 signaling pathway restricts immune-evasive virus replication. Mol Cell 2018;71(5):825-840.e6.

Kashpur O, Smith A, Gerami-Naini B, Maione AG, Calabrese R, Tellechea A, Theocharidis G, Liang L, Pastar I, Tomic-Canic M, Mooney D, Veves A, Garlick JA. Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes. FASEB J. 2019;33(1):1262-1277.

2017

 

Garlick JA, Levine P.  Where civics meets science: building science for the public good through Civic Science. Oral Dis. 23: 692-696. 

Chen CO, Smith A, Liu Y, Du P, Blumberg JB, Garlick J. Photoprotection by pistachio bioactives in a 3-dimensional human skin equivalent tissue model. Int J Food Sci Nutr. 25: 1-9. 

Higgins CA, Roger M, Hill R, Ali-Khan AS, Garlick J, Christiano AM, Jahoda CA.  Multifaceted role of hair follicle dermal cells in bioengineered skins. Br J Dermatol. 176: 1259-1269.

2016

Liang, L., Stone, R. C., Stojadinovic, O., Ramirez, H., Pastar, I., Maione, A. G., Tomic-Canic, M. Integrative Analysis of miRNA and mRNA Paired Expression Profiling of Primary Fibroblast Derived from Diabetic Foot Ulcers Reveals Multiple Impaired Cellular Functions. Wound Repair and Regeneration. doi:10.1111/wrr.12470

Garlick, J.A. Where Civics Meets Science: Building Science for the Public Good Through Civic Science. Oral Diseases (in press, 2016)

 

Gerami-Naini, B. Smith, A. Kashpur, O. and Garlick, J.A. Cell Therapies: New Frontier for the Management of Diabetic Foot Ulceration, in John Giurini, Raul Guzman and Aristedes Veves editors, The Diabetic Foot.  Medical and Surgical Management Humana Press (in press 2016)

 

Anna G. Maione,  Avi Smith, Vanessa Yanez, Olga Kashpur, Elana Knight, David J. Mooney, Aristidis Veves, Marjana Tomic-Canic, and Jonathan A. Garlick.  Altered ECM Deposition by Diabetic Foot Ulcer-Derived Fibroblasts Implicates Fibronectin in Chronic Wound Repair (in press, Wound Repair and Regeneration, 2016)  

 

Gerami-Naini, Behzad;Smith, Avi;Kashpur, Olga; Carpinito, Gianpaolo; Veves, Aristedes; Mooney, David; Garlick, Jonathan, Generation Of Induced Pluripotent Stem Cells From Diabetic Foot Ulcer Fibroblasts Using A Non-Integrative Sendai Virus (in press, Cellular Reprogramming 2016)

2015

Horacio A. Ramirez, Liang Liang, Irena Pastar, Ashley M. Rosa, Olivera Stojadinovic, Thomas G. Zwick, Robert S. Kirsner, Anna G. Maione, Jonathan A. Garlick, Marjana Tomic-Canic. Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin, PLOS ONE, August 28, 2015

 

Park, L., Maione, A., Smith, A., Gerami-Naini, B., Lyer, L., Mooney, D., Veves, A., and Garlick, J. Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblasts. Epigenetics, May DOI: 10.4161/15592294.201.

 

Chen, C.Y., Smith, A., Blumberg, J., and J. Garlick. Photoprotective Effects of Pistachio Antioxidants in a 3-Dimensional Human Skin Equivalent Tissue Model. FASEB J April 2015 29:922.24.

2014

 

Hewitt KJ, Shamis Y, Gerami-Naini B, Garlick JA. 2014. Strategies for oral mucosal repair by engineering 3D tissues with pluripotent stem cells. Adv Wound Care (New Rochelle) 3: 742-750.  

 

Maione AG, Brudno Y, Stojadinovic O, Park LK, Smith A, Tellechea A, Leal EC, Kearney CJ, Veves A, Tomic-Canic M, Mooney D, Garlick J. 2014. 3D human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds. Tissue Eng Part C Methods Epub ahead of print.  

2013

Shamis Y, Silva EA, Hewitt KJ, Brudno Y, Levenberg S, Mooney DJ, Garlick JA. 2013. Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo. PLoS One 8: e83755.

 

Evans-Johnson JA, Garlick JA, Johnson EJ, Wang XD, Oliver Chen CY. 2013. A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent. J Photochem Photobiol B. 126: 17-25.

 

Lucier RN, Etienne O, Ferreira S, Garlick JA, Kugel G, Egles C. 2013. Soft-tissue alterations following exposure to tooth-whitening agents. J Periodontol. 84: 513-519.

2012

Bellas E, Seiberg M, Garlick J, Kaplan DL. 2012. In vitro 3D full-thickness skin-equivalent tissue model using silk and collagen biomaterials. Macromol Biosci. 12: 1627-1636. ​

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Hewitt KJ, Garlick JA. 2012. Cellular reprogramming to reset epigenetic signatures. Mol Aspects Med. Epub ahead of print. books

Lucier R, Etienne O, Ferreira S, Garlick J, Kugel G, Egles C. 2012. Soft tissue alterations following exposure to tooth whitening agents(*). J Peridontol. Epub ahead of print.

Wittmer CR, Claudepierre T, Reber M, Wiedemann P, Garlick JA, Kaplan D, Egles C. 2011.​ Multifunctionalized electrospun silk fibers promote axon regeneration in central nervous system. Adv Funct Mater. 21: 4202.

Keller PJ, Arendt LM, Skibinski A, Logvinenko T, Klebba I, Dong S, Smith AE, Prat A, Perou CM, Gilmore H, Schnitt S, Naber SP, Garlick JA, Kuperwasser C. 2012. Defining the cellular precursors to human breast cancer. Proc Natl Acad Sci U S A. 109: 2772-2777.

Hewitt KJ, Shamis Y, Knight E, Smith A, Maione A, Alt-Holland A, Sheridan SD, Haggarty SJ, Garlick JA. 2012. PDGFRβ Expression and Function in Fibroblasts Derived from Pluripotent Cells is Linked to DNA Demethylation. J Cell Sci. 125 (Pt9): 2276-2287.

Shamis Y, Hewitt KJ, Bear SE, Alt-Holland A, Qari H, Margvelashvilli M, Knight EB, Smith A, Garlick JA.  2012. iPSC-derived fibroblasts demonstrate augmented production and assembly of extracellular matrix proteins. In Vitro Cell Dev Biol Anim. 48: 112-122.

Desrochers TM, Shamis Y, Alt-Holland A, Kudo Y, Takata T, Wang G, Jackson-Grusby L, Garlick JA.  2012. The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma. Epigenetics. 7: 34-46.

2011

Alt-Holland A, Sowalsky AG, Szwec-Levin Y, Shamis Y, Hatch H, Feig LA, Garlick JA. 2011. Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src. J Invest Dermatol. 131: 2306-2315.

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Carlson MW, Garlick JA, Solomon LW. 2011. Chronic ulcerative stomatitis: evidence of autoimmune pathogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 111: 742-748.

Hewitt KJ, Shamis Y, Hayman RB, Margvelashvili M, Dong S, Carlson MW, Garlick JA. 2011. Epigenetic and phenotypic profile of fibroblasts derived from induced pluripotent stem cells. PLoS One 6: e17128.

Shamis Y, Hewitt KJ, Carlson MW, Margvelashvilli M, Dong S, Kuo CK, Daheron L, Egles C, Garlick JA. 2011. Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents. Stem Cell Res Ther. 21: 10.

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA. 2011. RalA function in dermal fibroblasts is required for the progression of squamous cell carcinoma of the skin. Cancer Res. 71: 758-767. Abstract in PubMed

2010

Gomes HJ, Dong S, Wein RO, Garlick JA. 2010. Fabrication of 3-dimensional tissue models to study head and neck squamous cell carcinoma. Laryngoscope 120: S142.

Xu K, Rajagopal S, Klebba I, Dong S, Ji Y, Liu J, Kuperwasser C, Garlick JA, Naber SP, Buchsbaum RJ. 2010. The role of fibroblast Tiam1 in tumor cell invasion and metastasis. Oncogene 29: 6533-6542.

Egles C, Huet HA, Dogan F, Cho S, Dong S, Smith A, Knight EB, McLachlan KR, Garlick JA. 2010. Integrin-blocking antibodies delay keratinocyte re-epithelialization in a human three-dimensional wound healing model. PLoS One 5: e10528.

Egles C, Garlick JA, Shamis Y. 2010.  Three-dimensional human tissue models of wounded skin. Methods Mol Biol. 585: 345-359. 

2009

Etienne O, Schneider A, Kluge JA, Bellemin-Laponnaz C, Polidori C, Leisk GG, Kaplan DL, Garlick JA, Egles C. 2009. Soft tissue augmentation using silk gels: an in vitro and in vivo study. J Periodontol. 80: 1852-1858.

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA. 2010. RalA suppresses early stages of Ras-induced squamous cell carcinoma progression. Oncogene 29: 45-55. Abstract in PubMed

Hewitt KJ, Shamis Y, Carlson MW, Aberdam E, Aberdam D, Garlick JA. 2009. Three-dimensional epithelial tissues generated from human embryonic stem cells. Tissue Eng Part A 15: 3417-3426.

Schneider A, Wang XY, Kaplan DL, Garlick JA, Egles C. 2009. Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater. 5:2570-2578.

2008

Carlson MW, Alt-Holland A, Egles C, Garlick JA. 2008. Three-dimensional tissue models of normal and diseased skin. Curr Protoc Cell Biol. Chpt 19, Unit 19.9. 

Alt-Holland A, Shamis Y, Riley KN, DesRochers TM, Fusenig NE, Herman IM, Garlick JA. 2008. E-cadherin suppression directs cytoskeletal rearrangement and intraepithelial tumor cell migration in 3D human skin equivalents. J Invest Dermatol. 128: 2498-2507.

Egles C, Shamis Y, Mauney JR, Volloch V, Kaplan DL, Garlick JA. 2008. Denatured collagen modulates the phenotype of normal and wounded human skin equivalents. J Invest Dermatol. 128: 1830-1837. books

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Schneider A, Garlick JA, Egles C. 2008. Self-assembling peptide nanofiber scaffolds accelerate wound healing. PLoS One 3: e1410.

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Segal N, Andriani F, Pfeiffer L, Kamath P, Lin N, Satyamurthy K, Egles C, Garlick JA. 2008. The basement membrane microenvironment directs the normalization and survival of bioengineered human skin equivalents. Matrix Biol. 27: 163-170.

2007 and earlier

Garlick JA. 2007. Engineering skin to study human disease--tissue models for cancer biology and wound repair. Adv Biochem Eng Biotechnol. 103: 207-239.

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Zhang W, Alt-Holland A, Margulis A, Shamis Y, Fusenig NE, Rodeck U, Garlick JA. 2006. E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion. J Cell Sci (Pt2)  119: 283-291. books

Margulis A, Zhang W, Alt-Holland A, Pawagi S, Prabhu P, Cao J, Zucker S, Pfeiffer L, Garfield J, Fusenig NE, Garlick JA. 2006. Loss of intercellular adhesion activates a transition from low- to high-grade human squamous cell carcinoma. Int J Cancer 118: 821-831.

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Greenberg S, Kamath P, Petrali J, Hamilton T, Garfield J, Garlick JA. 2006. Characterization of the initial response of engineered human skin to sulfur mustard. Toxicol Sci. 90: 549-557. Abstract in PubMed

CIVIC SCIENCE 

Garlick, JA, Soisson, A, Bergom, I.Design and Impact of an Undergraduate Civic Science Course (2020).  Journal of College Science Teaching, Volume 49 (4), March/April.


Kotsias, V, Garlick, J, Cole, A, Kwon, S, Lightfoot, A, Concannon, T and LeClair, AM. (2020) Facilitating Stakeholder Engagement in Early Stage Translational Research. PLOS ONE https://doi.org/10.1371/journal.pone.0235400. 


Garlick, JA and Levine, P. (2017) Where civics meets science: Building science for the public good through Civic Science, Oral Diseases, 23:692-696.

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Department of Diagnostic Sciences

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Tel: 617-636-2478

Email us: garlicklab@tufts.edu

 

© 2019 Nathan Ashby

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