Self-Assembly (SA)
The SA model was designed to specifically model the dermal layer of the tissue in a higher throughput format. By utilizing a fully human and fibroblast specific extracellular matrix, this system is able to better model dermal disease phenotypes and responses to therapeutics
Fibroblast produced dermis
Applications
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Disease modeling
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Dermal response
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Mouse xenografting
Cell Types
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Fibroblasts
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Monocytes
Readouts
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Histology
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Immunohistochemistry
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Extracellular matrix production and organization
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Extracellular matrix components
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Tissue stiffness and contraction
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Protein expression
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Gene expression
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Cytokine secretion