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Self-Assembly (SA)

The SA model was designed to specifically model the dermal layer of the tissue in a higher throughput format. By utilizing a fully human and fibroblast specific extracellular matrix, this system is able to better model dermal disease phenotypes and responses to therapeutics

Fibroblast produced dermis

       Applications

  • Disease modeling

  • Dermal response

  • Mouse xenografting

       Cell Types

  • Fibroblasts

  • Monocytes

       Readouts

  • Histology 

  • Immunohistochemistry

  • Extracellular matrix production and organization

  • Extracellular matrix components 

  • Tissue stiffness and contraction

  • Protein expression

  • Gene expression

  • Cytokine secretion