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Self-Assembly Skin Equivalent (SASE)

The SASE is our newest model, which combines the higher throughput fibroblast specific dermal layer with a full thickness epidermis. This system can therefore be used to create disease or even patient specific skin equivalents for therapeutic testing and development. 


Full thickness epidermis

Fibroblast produced dermis 


  • Disease modeling

  • Dermal response

  • Keratinocyte proliferation and differentiation

  • Mouse xenografting

  • Wound Healing

  • Cytotoxicity 

       Cell Types

  • Keratinocytes

  • Fibroblasts

  • Monocytes


  • Histology 

  • Immunohistochemistry

  • Extracellular matrix production and organization

  • Extracellular matrix components

  • Tissue stiffness and contraction

  • Protein expression

  • Gene expression

  • Cytokine secretion

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