Self-Assembly Skin Equivalent (SASE)

The SASE is our newest model, which combines the higher throughput fibroblast specific dermal layer with a full thickness epidermis. This system can therefore be used to create disease or even patient specific skin equivalents for therapeutic testing and development. 

SkinmodelSASE.png

Full thickness epidermis

Fibroblast produced dermis 

       Applications​

  • Disease modeling

  • Dermal response

  • Keratinocyte proliferation and differentiation

  • Mouse xenografting

  • Wound Healing

  • Cytotoxicity 

       Cell Types

  • Keratinocytes

  • Fibroblasts

  • Monocytes

       Readouts

  • Histology 

  • Immunohistochemistry

  • Extracellular matrix production and organization

  • Extracellular matrix components

  • Tissue stiffness and contraction

  • Protein expression

  • Gene expression

  • Cytokine secretion

SA-KCfig.png